White Papers Archive - Pharmaceutical Technology

MIRAI X CRYO Product Portfolio ‒ Process Cooling from -120⁰C to +50⁰C

Nat Schaefer — Wed, 17 Apr 2024 14:20:36 +0000

This free white paper offers an overview of MIRAI INTEX's MIRAI X CRYO product range, which is designed for process cooling from -120°C to +50°C.

ISO 14644-1 Cleanroom-Compatible Equipment to Ensure Good Manufacturing Practice

Nat Schaefer — Wed, 17 Apr 2024 11:53:34 +0000

Cleanrooms are defined as environments within which the concentration of airborne particles is controlled. They are designed and operated in a manner to control the introduction, generation, and retention of particles inside the room. Several industries like life sciences, aerospace, electronics use cleanrooms.

PROTAC Building Blocks

Nat Schaefer — Tue, 16 Apr 2024 10:02:24 +0000

Targeted protein degradation (TDP) has been an attractive concept in the drug discovery to selectively remove the disease-causing proteins from the system, and remained as academic interest for several decades until the recent discovery of small molecule proteolysis-targeting chimera (PROTAC) protein degraders.

Lexitropsin Building Blocks

Nat Schaefer — Tue, 16 Apr 2024 09:54:46 +0000

The naturally occurring oligopeptide antibiotics Netropsin and Distamycin not only represent important paradigms of sequence-selective DNA minor groove binders but also provide important direction to discover anti-cancer agents with high specificity.

Heterocyclic Building Blocks

Nat Schaefer — Tue, 16 Apr 2024 09:48:11 +0000

Heterocyclic compounds are ubiquitous in nature, and the ring systems commonly appear in many drugs and natural products approved by FDA for a wide range of therapeutic areas.

Chemical Biology Building Blocks

Nat Schaefer — Tue, 16 Apr 2024 09:45:21 +0000

Chemical Biology research uses the tools of chemistry and synthesis to understand biology and pathogenesis at the molecular level and hence addresses fundamentally important questions in biology, medicine, and drug discovery.

Troubleshooting Tablet Defects in No Time

Nat Schaefer — Thu, 28 Mar 2024 12:58:57 +0000

There are numerous tablet defects: chipping, picking and sticking, cracking, lamination, and capping to name a few.

Using the STYL’One Nano Compaction Simulator to Characterise Round and Oblong Itraconazole Amorphous Solid Dispersions Tablets

Nat Schaefer — Tue, 19 Mar 2024 11:05:24 +0000

Itraconazole (ITZ) is an antifungal drug commercially available as an oral solution or more commonly as 100mg capsules. It has been reported that the bioavailability of the oral solution is only 55%.

Design of Experiments (DOE): An Essential Tool to Better Understand Tablet Formulations

Nat Schaefer — Tue, 19 Mar 2024 11:01:15 +0000

This free white paper covers a brief overview of the steps for pharmaceutical product development under the quality by design (QbD) framework; introduces design of experiments (DoE) applied to formulation of tablets and gives an example of how to design piroxicam amorphous solid dispersions (ASD) tablets using DoE.

Compaction Characterisation of Piroxicam Amorphous Solid Dispersions Formulations

Nat Schaefer — Tue, 19 Mar 2024 10:58:35 +0000

Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs.