ELVN-002 is a small molecule commercialized by Enliven Therapeutics, with a leading Phase I program in Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer). According to Globaldata, it is involved in 4 clinical trials, of which 2 are ongoing, and 2 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of ELVN-002’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for ELVN-002 is expected to reach an annual total of $12 mn by 2037 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
ELVN-002 Overview
ELVN-002 is under development for the treatment of solid tumors including non-small cell lung cancer, HER2 positive breast cancer, gastric cancer and colorectal cancer. It acts by targeting human epidermal growth factor receptor 2 (HER2), and key mutations of HER2. It is administered through oral route.
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Enliven Therapeutics Overview
Enliven Therapeutics, formerly a Imara, is a clinical-stage precision oncology company that discovers and develops small molecule kinase inhibitors. The company product pipeline includes ELVN- 001 and ELVN- 002. Its product treats chronic myeloid leukemia (CML), non-small cell lung cancer (NSCLC) and solid tumors. Enliven Therapeutics pipeline program includes BCR-ABL and HER2 which carries out gene fusion, oncogenic, small molecule inhibitors and HER2 mutations including exon 20 insertion mutations (E20IMs) in non-small cell lung cancer (NSCLC). The company also includes ABL 1 tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia. Enliven Therapeutics is headquartered in Boulder, Colorada, the US.
The operating profit of the company was US$0.7 million in FY2022, compared to an operating loss of US$51.4 million in FY2021. The net profit of the company was US$1.5 million in FY2022, compared to a net loss of US$51.4 million in FY2021.
For a complete picture of ELVN-002’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
